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This work reports the noninvasive image-based quantification of swelling in an atopic dermatitis mouse model on the basis of cellular-level deep understanding analysis of coherent anti-Stokes Raman scattering and stimulated Raman scattering imaging. This quantification technique enables timepoint-specific infection ratings making use of morphological and physiological measurements. The outcome we show set the stage for applying this workflow to future medical studies.Artificial Int