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Loss of MsrAB triggered 1000-fold upsurge in susceptibility of Hi to HOCl-mediated killing, and in addition decreased biofilm formation and in-biofilm survival. Appearance of msrAB has also been induced by hydrogen peroxide and paraquat, but a Hi2019ΔmsrAB stress had not been at risk of killing by these ROS in vitro. Hi2019ΔmsrAB physical fitness in disease models had been reduced, with a 3-fold reduction in intracellular survival in bronchial epithelial cells, increased susceptibility