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A complete of 4 genes (TROAP, PCOLCE2, HOXA4, and C1Q in Hyper-LGs and 14 genes (DYNC1H1, LNX1, RAB37, ALDH3A1, SLC24A4, CP, CEP250, ANK2, DNAI2, MUC13, ACACB, GABRP, STX7, and TTC9) in Hypo-HGs were identified as hub genes.The study of DNA methylation and gene expression provides us a strong assistance also new extensive information of MDEGs towards the revelation of nasopharyngeal carcinoma's complex pathogenesis. Nonetheless, additional studies are needed