https://www.selleckchem.com/products/gdc-0032.html
We further find that disruption of this network in TmrA versus TmrB has different functional consequences, hinting at an intrinsic asymmetry in heterodimeric ABC transporters extending beyond that of the NBDs. These results support a mechanism in which the GRD motifs help coordinate a transition to an outward open conformation, and each half of the transporter likely plays a different role in the conformational cycle of TmrAB.Cofilin is an essential actin filament severing protein that accelerates the assembly dynamics and turnover of
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