https://www.selleckchem.com/pr....oducts/Cyclopamine.h
Macrophages help defend the host against Mycobacterium tuberculosis (Mtb), the major cause of tuberculosis (T. Once phagocytized, Mtb resists killing by macrophages, replicates inside them, and leads to their death, releasing Mtb that can infect other cells. We found that the death of Mtb-infected mouse macrophages in vitro does not appear to proceed by a currently known pathway. Through genome-wide CRISPR-Cas9 screening, we identified a critical role for autocrine or paracrine signaling by macrophage-derived type I IFNs in the de
Like
Comment
Share
