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The performance indicators employed here are (i) GWP, (ii) temperature glide, (iii) volumetric capacity, and (iv) coefficient of performance. The advantages to reduce the irreversible heat loss by glide matching and energy saving potential for the blends are also discussed. Results showed that some refrigerant blends considering GWP 200 and 300 could successfully replace the widely used R410A in a residential air conditioner. Thermodynamic cycle and performance of zeotropic blend.The pandemic shock puts the world o