https://www.selleckchem.com/pr....oducts/JNJ-26481585.
Of particular interest, several receptors signalling via Gαs or Gαq showed significant mRNA upregulation in islets from obese donors (fold increase PTH2R 54.0 ± 14.6; MC2R 34.3 ± 11.5; RXFP1 8.5± 2.1; HTR2B 6.0 ± 2.0; GPR110 3.9± 1.2; PROKR2 3.9± 0.7). Under conditions of obesity, human islets showed significant alterations in mRNAs encoding numerous GPCRs. The increased expression of Gαs- and Gαq-coupled receptors that have not previously been investigated in β-cells opens up possibilities of novel therapeutic candidates that may
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