https://www.selleckchem.com/pr....oducts/epz005687.htm
Non-linear mixed effects modeling was carried out to characterize dacomitinib pharmacokinetics in the presence and absence of the concomitant use of a PPI, rabeprazole. Several absorption models, some more empirical, and some more physiologically based, were tested transit compartment, first-order absorption with and without lag time, and variations of combined zero- and first-order absorption kinetics models. RESULTS The presence of a PPI was a significant covariate affecting the extent (F) and rate (ka) of dacomitinib absorption, as
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