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5%). Sex of patients (P=0.001), margin (P=0.003) and focality (P=0.01) of the nodule were independent risk factors for metastasis, whereas sex of the patients (P=0.004) and margin (P=0.00 were independent risk factors for perithyroidal invasion. By Kaplan-Meier analysis, survival proportions different between groups with/without perithyroidal extension (P=0.00 but not between groups with/without metastasis (P=0.473). High frequency ultrasound and TI-RADS were effective methods for preoperative diagnosis of MTC. Sex of the patients and margi