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04). In the control group, there were no significant changes in hormone levels between seasons or any correlations between neurohormone levels and the ipRGC-mediated responses. The two groups showed a similar response to season with lower depression scores in summer compared with winter. In between-group comparison, the nocturnal melatonin level (area under curve from 2000 h to 0800 h) in summer was lower in glaucoma compared with controls (p = .03). In winter, nocturnal cortisol (at 0400 h) was lower (p = .004) and daytime cortisol (12