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cale trials. Adaptations of interventions were common and may have impacted on the effectiveness of interventions delivered at scale. These outcomes provide valuable insight for researchers and public health practitioners interested in the design and scale-up of physical activity interventions, and contribute to the growing evidence base for delivering health promotion interventions at-scale. PROSPERO CRD42020144842 . PROSPERO CRD42020144842 . Silver-Russell syndrome (SRS) is an imprinting disorder which is characterised by severe primo