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This work provides an effective strategy for augmenting CO-mediated antitumor efficacy by remodeling the tumor microenvironment. Nurses play an important role in pharmaceutical care. They are involved in detecting clinical change; communicating/discussing pharmacotherapy with patients, their advocates, and other healthcare professionals; proposing and implementing medication-related interventions; and ensuring follow-up of patients and medication regimens. To date, a framework of nurses' competences on knowledge, skills, and attitude