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The Most Effective ADHD Medication For Adults Stimulants are the most effective treatment for adults suffering from ADHD. They aid in regulating levels of two chemical signals in the brain which control attention. Strattera (atomoxetine) is the most effective medication for adhd available for adults. It is an oral capsule that can be taken either with or without food. It is suitable for the majority of people. It lasts longer than stimulants that have an action time that is shorter like amphetamine or methylphenidate. 1. Strattera Strattera (atomoxe