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Some genotypes of mutations show ethno-correlation, and among them, genetic Creutzfeldt-Jacob disease (gCJD) with V210I mutation is regular in europe but unusual in East Asia. Right here, we relatively examined the clinical and laboratory popular features of three Chinese clients with V210I mutant identified through the Chinese National CJD Surveillance System (CNS-CJD) in 2019. Two cases were Han Chinese and another was Hui Chinese, without bloodst