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Antibiotics are overly prescribed in nursing homes. Recent antibiotic stewardship efforts attempt to reduce inappropriate use. Our objective was to describe antibiotic use from 2012 to 2016 among nursing-home residents with various health conditions. Retrospective, repeated cross-sectional analysis. All long-term residents in a random 10% sample of national nursing homes 2,092,809 assessments from 319,615 nursing-home residents in 1,562 nursing homes. We calculated a 1-day antibiotic prevalence using all annual and quarterly clinical as