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Current standard-of-care treatment plan for higher level RCC involves combination TKI and immunotherapy regimens including cabozantinib and nivolumab as studied into the CheckMate 9ER test. This review summarizes the preclinical and clinical proof that led to the CheckMate 9ER study, as well as important study aspects such treatment effectiveness, damaging events and patient-related outcomes.The restriction of intramolecular movement (RIM) and limited access to a conical intersectio