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Ten new CrAg-positives had been identified through repeat testing. A CrAg titer cut-point of ≥180 provided top discrimination for 6-month success. CONCLUSIONS CrAg-positivity rates in an ART-experienced populace were similar to those observed in ART-naïve populations. Repeat assessment identified people who seroconverted to CrAg-positivity and were at risk of cryptococcal disease. CrAg titers ≥180 can help identify the individuals at greatest threat of death for more intensive manageme