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Early after break (range 2-4 days), enhanced expression of CXCL12, recommended recruitment of protected cells related to a change in the balance of degradation enzymes and their inhibitors. At advanced time after break (4-8 days), we noticed high expression of inflammatory cytokines (IL1-beta, IL6), CCL2, the T-cell activation marker CD69. Late after fracture (8-14 days), high appearance of elements co-operating towards the legislation of bone tissue turnover had been detected. We i