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Whereas many studies showed no effect for antiviral treatment on colectomy rates in CMV infected UC patients , there was a significant difference in colectomy rates of patients with high-grade infection who received anti-viral therapy compared to those who did not receive treatment. It was therefore proposed that high-grade CMV disease indicates that the virus is acting as a pathogen, whereas in those with low-grade CMV disease, the severity of IBD itself is more likely to influence outcome. The different algorithms that have been put fo