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To evaluate the evolution of river water quality in a changing environment, measuring the objective water quality is critical for understanding the rules of river water pollution. Based on the sample entropy theory and a nonlinear statistical method, this study aims to identify the spatiotemporal dynamics of water quality and its complexity in the Yangtze River basin using time series data, to separate the contributions of human activity and climate change to water quality, and to establish a data-driven risk assessment framework for the