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This research was carried out to determine the crucial part of this NLRP3 inflammasome and high-mobility team field 1 (HMGB1) in sevoflurane-induced intellectual impairment. On gestational day 20 (G2, 3% sevoflurane was administered for 4 h to pregnant rats. The hippocampus and cerebral cortex of the offspring were harvested at postnatal time 1 (P1) for west blotting and immunofluorescence staining. Pregnant rat sevoflurane exposure enhanced the necessary protein quantities of NLRP3, ASC,
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