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A treatment for PTSD is proposed that combines exposure to trauma-related cues with neurofeedback-mediated regulation of arousal.Conclusions Our analysis argues for the integration of hyperarousal-targeting interventions into existing therapies. Accordingly, we offer methodological considerations based on the nested hierarchy principle that can guide such integration. To evaluate the targetability of late-stage cervical cancer by magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-induced hyperthermia (HT) as an adjuvant