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To evaluate the modalities of methotrexate prescription for moderate to severe psoriasis by dermatologists in France. We performed a national online practice survey between October and December 2020. A total of 254 dermatologists responded, 237 reported prescribing methotrexate for moderate to severe psoriasis in adults, of which 57% as a first line systemic treatment. Nineteen percent reported performing a test dose at the initiation of treatment. Methotrexate was prescribed orally in 54.7% of cases, subcutaneously in 44.8% of cases and i