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Right here, we reported that the amount of 5-hydroxymethylcytosine (5-hmC) in personal HCC tissues was somewhat less than that in adjacent liver tissues, and paid down 5-hmC substantially correlated with malignant phenotypes, including poor differentiation and microvascular intrusion; additionally, loss in 5-hmC was related to chemotherapy resistance in post-transplantation HCC patients. More, the 5-hmC level was regulated by ten-eleven translocation 2 (TET2), therefore the decr