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The Most Effective ADHD Medication For Adults Stimulants are the most effective treatment for adults suffering from ADHD. They aid in adjusting levels of two chemical messengers within the brain that regulate attention. The most effective medication for adhd for adults is Strattera (atomoxetine). It is an oral capsule that can be taken either with or without food. It is effective for a majority of people. It lasts longer than stimulants that have an action time that is shorter