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TEM revealed a 20 μm thick hydrophobic adhesive layer with a homogeneous bioglass filler circulation. Adequate polymerization conversion triggered acutely low water sorption and solubility. In situ zymography disclosed decreased endogenous proteolytic task, while Streptococcus mutans biofilm development ended up being inhibited. To conclude, the three-/two-step ER/SE Exp_2UA integrates the large bonding potential and bond degradation opposition with long-lasting ion release, maki