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How Does ADHD Medication Work? Stimulants are the first option for treating ADHD. They regulate the levels of neurotransmitters (two brain chemicals) that transmit messages between neurons in order to improve attention and reduce excessive hyperactivity. However, as much as 20 percent of people don't respond to the most frequently prescribed stimulants, methylphenidate or amphetamine. This could be due to the chemistry of the body of the person or other medications that they are taking. What are the signs of ADHD? If y