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Purpose Radiation-related caries is characterized by enamel delamination near the dentinoenamel junction (DEJ). We investigated the activity and expression of the matrix metalloproteinases (MMPs) -2 and -9 in order to understand disease pathogenesis in teeth submitted or not to radiotherapy (RT). Conclusion Radiotherapy can increase the activity of MMPs -2 and -9 in the cervical region of the DEJ of primary teeth.Purpose To investigate the effect of full-mouth rehabilitation on the levels of Streptococcus mutans and Streptococcus sobrinu