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Experimental validation of the system's navigated ultrasound component demonstrated accuracy of [Formula see text] and a frame rate of 25 frames per second. Clinical simulation confirmed that system assembly was straightforward, could be achieved in a clinically acceptable time of [Formula see text] and performed with a clinically acceptable level of accuracy. We present an integrated open-source research platform for multi-modality IGS. The present prototype system was tailored for neurosurgery and met all minimum design requirements f