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32, 95% CI = 1.48-363, P = 0.02). Conclusion The meta-analysis revealed that over-expression of β-catenin might be associated with distant metastasis and overall survival in osteosarcoma, which reminds that β-catenin acts as a prognostic biomarker and it can guide the clinical therapy in osteosarcoma patients. Copyright © 2020 Xie, Li, Zhu, Kuang, Chen and Fan.Purpose Our current understanding of low-grade brainstem glioma (LGBSG) is still limited. This study aimed to conduct a large-scale population-based real-world study to understand