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interval neuroimaging after initial treatment of glioblastoma within the UK. • Large, multicentre, longitudinal, prospective trials are needed to define the optimal imaging schedule for assessment. To assess how modifying multiple protocol parameters affects the dose and diagnostic performance of a neck CT protocol using patient-mimicking phantoms and task-based methods. Six patient-mimicking neck phantoms containing hypodense lesions of 1cm diameter and 30HU contrast and one non-lesion phantom were examined with 36 CT protocols. All possible combinations o