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better tailor health behavior interventions. The appropriate medical treatment for gestational diabetes mellitus (GDM) is controversial and recommendations vary between different organizations. To compare the safety and efficacy of glyburide and insulin as treatments for GDM. Retrospective analysis of all pregnant women diagnosed with GDM and treated with either glyburide or insulin. Demographic features, clinical characteristics, maternal and neonatal outcomes were compared according to type of pharmacological treatment. Included in the