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rrelated with poor outcomes of BC patients receiving chemotherapy. Conclusions Our findings clarify the roles and mechanisms of SRGN in mediating chemoresistance in breast cancer and suggest its use a potential biomarker for chemotherapeutic response. We believe that novel therapeutic strategies for breast cancer can be designed by targeting the signaling mediated by the crosstalk between SRGN and YAP. © The author(s).Background Evidence suggests that pathophysiological conditions such as obesity and type 2 diabetes (T2D) are associated