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Among these substances, 13 exhibits potent binding affinity (IC50 = 7.6 ± 0.9 nM), good allosteric modulator (PAM) task (EC50 = 51.2 nM), and exceptional selectivity against various other mGluR subtypes (100-fold). [11C]13 had been synthesized via O-[11C]methylation of its phenol precursor 25 with [11C]methyl iodide. The attained radiochemical yield was 20 ± 2% (letter = 10, decay-corrected) based on [11C]CO2 with a radiochemical purity of 98% and molar activity of 98 ± 30 GBq/
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