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The Most Effective ADHD Medication For Adults Stimulants are the first choice of treatment for adults suffering from ADHD. They help adjust levels of two chemical messengers in the brain that control attention. Strattera (atomoxetine) is the most effective treatment for adhd available for adults. It comes as an oral capsule that can be taken with or without food. It is suitable for the majority of people. It lasts longer than stimulants with less time to take effect, such