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; Pre-results. With a marginally effective vaccine and no significant breakthroughs in new treatments, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. The analysis of multiple cytokine profiles provides the possibility to differentiate the two diseases. Systematic review and meta-analysis. PubMed, Cochrane Library, Clinical Key and EMBASE databases were searched on 31 December 2019. We included case-control st