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02,95%CI1.01-1.03), lower urinary catheter (OR=0.37,95%CI0.26-0.48) and lower Pitt score (OR=0.76,95%CI0.71-0.82). Adjusted estimations considering patients' features and exposure to procedures showed a reduction in coagulase-negative staphyloccoci (OR=0.47;95%CI0.32-0.69); and an increase in Proteus spp. (OR=3.12;95%CI1.18-8.23) and Candida spp. (OR=3.01;95%CI1.03-8.86). Conclusions We found relevant epidemiological changes in BSI in our area, including rates, frequency of acquisition types, changes in patient's profiles and in etiol