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How to Choose the Best ADHD Medication for Adults With Anxiety and Depression When a person has both ADHD and depression or anxiety, treating one condition often improves the other. Mental health professionals prescribe antidepressants, stimulants for depression, or antidepressants in conjunction with ADHD medication. Wellbutrin (bupropion), and Effexor, (venlafaxine), are the two most commonly used antidepressants prescribed for ADHD "off-label". These medications increase the l