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in the arylselanyl moiety. The tested compounds presented significant antioxidant potential in the tests of inhibition of DPPH, ABTS+ and NO radicals, as well as in the FRAP and superoxide dismutase-like activity assays (SOD-Like). Copyright© Bentham Science Publishers; For any queries, please email at [email protected] This study aims to synthesize and characterize 2,4-thiazolidinediones and evaluate their antitumor activity. METHOD TZDs were synthesized from three components 2,4-thiazolidinedione, arene-aldehydes, and