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It has no effect on children with gastroenteritis who do not present with dehydration in developing countries. While ondansetron is effective in controlling vomiting and reducing the rate of hospitalization, there is no evidence that it is effective in reducing the rate of readmission.What is Known• In high-income countries, ondansetron can reduce the use of intravenous fluids in children with gastroenteritis and dehydration.• No systematic review and meta-analysis of randomized controlled trials were done in a developing country setting.Wh