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This review may result in a great guidance of noncoding RNAs as biomarkers for ACS in clinical practice. Copyright © 2020 Lijie Wang and Yuanzhe Jin.Objective To investigate the association between exposure to general anesthesia and the development of Alzheimer's disease (AD) and dementia by reviewing and integrating the evidence from epidemiological studies published to date. Methods We searched MEDLINE, EMBASE, and Google Scholar to identify all relevant articles up to April 2018 reporting the risk of AD/dementia following exposure to