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be used to design targeted HCV programs among people who are at higher risk of infection. We aimed to assess whether machine learning models are superior at predicting acute kidney injury (AKI) compared to logistic regression (LR), a conventional prediction model. Eligible studies were identified using PubMed and Embase. A total of 24 studies consisting of 84 prediction models met inclusion criteria. Independent samples t-test was performed to detect mean differences in area under the curve (AUC) between ML and LR models. One-way ANOVA a