https://www.selleckchem.com/pr....oducts/cdk2-inhibito
The in vitro release of PVP-K90 was in the following order PVP-coated contact lens (168 h) DL-SM-PVP (168 h) DL-PVP (96 h) SM-PVP (72-96 h). PVP-coated contact lenses showed a high burst effect (lubricating effect) and sustained release (3161-448 ng/h between 24 and 168 h) due to high PVP loading/coating in comparison to the uncoated respective contact lenses (964-113 ng/h between 24 and 96 h). In animal studies, the PVP-K90-coated contact lens showed higher tear volume in comparison to the respective uncoated c