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Tetralogy of Fallot is characterized by the presence of four congenital heart defects. Objective to describe the temporal trend and distribution of Tetralogy of Fallot, in children under one year in the Valencian Region. Cases with Tetralogy of Fallot (code Q21.3 from the ICD10-British Paediatric Association) were selected from the Congenital Anomalies Population-based Registry between 2007-2017. Prevalence per 10,000 births with 95%CI was calculated, and a descriptive analysis of sociodemographic and clinical variables was made. 165 ca