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High senescence and low autophagy were observed in cervical stromal cells under OS. Conversely, senescence was low and autophagy was high in endocervical epithelial cells. OS induced p38MAPK activation in all three cervical cells but only increased IL-6 production by the ectocervical epithelial cells. Inhibition of IL-6 production by a p38MAPK inhibitor confirmed activation of an OS-induced pathway. In conclusion, OS can promote different forms of cell death and sterile inflammation that is likely mediated by p38MAPK activation in the c