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An instant, sensitive and painful, and particular strategy was created and effectively applied to gauge the pharmacokinetic (PK) properties of SH-1028 in patients with advanced NSCLC following single and multiple doses of SH-1028 (60 mg).After single-dose administration, the Cmax of SH-1028, Imp2, and Imp3 was 11.2, 50.2, and 7.99 ng/mL, correspondingly. The mean AUC0-24 h had been 138, 602, and 76.7 h*ng/mL, respectively. Together with terminal half-life time was 19