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Our data reveal that the activity of BK networks was inhibited in cerebral artery SMCs (CASMCs) from mice after intraperitoneal injection of TAC once a day for 30 days. The voltage sensitivity, Ca2+ sensitivity, and available time of solitary BK channels were all reduced. In help, BK station β1-, but not α-subunit necessary protein phrase ended up being substantially diminished in cerebral arteries. In TAC-treated mice, application of norepinephrine induced stronger vasoconstriction in both cere