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Our experimental results show that the real three-dimensional microstructure of nonwovens can be reconstructed well by using this new depth from focus method, which is very useful for the accurate modeling and analysis of nonwoven fabrics.Nitric oxide (NO) regulates various physiological and pathophysiological functions in the lungs. However, there is much less information about the effects of NO in the pleura. The present review aimed to explore the available evidence regarding the role of NO in pleural disease. NO, has a double-edged