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The purpose of this meta-analysis would be to assess the results of intravenous dexmedetomidine on hemodynamic response (blood circulation pressure and heart rate) resulting from the use of skull-pin head-holder in neurosurgery. Customers and practices A systematic review and meta-analysis had been performed according to the most well-liked Reporting Items for organized Reviews and Meta-Analyses (PRISMA) declaration instructions. The protocol ended up being s