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Patients with classical dermal lesions were younger (P less then 0.0001) and had a smaller number of lesions (P less then 0.05) than those without the lesions. The lesion(s) resolved in 24 of the 44 untreated cases within 1 week to 19 months. Refractory or recurrent lesion(s) were seen in four of 21 treated cases and in four of 44 untreated cases. Because subcutaneous granuloma annulare lesions often resolve spontaneously without treatment, invasive treatments should be avoided. © 2020 Japanese Dermatological Association.Immune checkpoi
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